Ann Littlewood started working at Storthes Hall Hospital in 1968, initially as a part-time Nursing Assistant. In 1976, she commenced the three year training course as a Student Nurse and gained the Registered Mental Nurse qualification in 1979. Between 1980 and 1981, she was seconded to Huddersfield Royal Infirmary as a post-graduate student and achieved the State Registered Nurse qualification.
In June 1981 she returned to Storthes Hall to manage shift 2 on Ward 10. In 1984 she moved to St. Luke's Hospital with a group of nurses to set up a ward for dementia assessment. Following this, she was promoted to Nursing Officer, initially in charge of a medical unit for the elderly, also at St. Luke's, and later as manager of the psycho geriatric unit which included the dementia assessment ward.In 1989, she became the Directorate Nurse Manager for the Mental Health Directorate and finally, the Senior Nurse for Mental Health, retiring from this post in 1999.